Understanding the link between loneliness, mental health, and addiction
12th May 2025 / Written by Harbor London
In our interconnected – yet increasingly isolated – society, the feeling of loneliness when surrounded by people has become an undeniable phenomenon. Loneliness, often misunderstood as simply physical solitude, is better defined as “a subjective, negative feeling related to deficient social relations” or “a feeling of disconnectedness or isolation”1 Recent figures reveal its prevalence, with approximately a quarter (27%) of adults in the UK reporting feelings of loneliness2.
But the significance of loneliness lies in its profound implications for emotional wellbeing and overall health. Chronic social isolation and loneliness negatively impact physical and mental health1, with consequences comparable to established health risks such as smoking, obesity, and physical inactivity3. For example, it can indicate underlying depression4, is linked to increased suicidal ideation and para-suicide5 and elevates risks for Alzheimer’s disease and other dementias6-7.
The complex nature of loneliness
Loneliness and isolation are terms often mistakenly used interchangeably, yet they represent fundamentally different experiences. Loneliness refers to the distressing sensation of feeling disconnected from others8. Whereas social isolation pertains to an actual lack of social contact or supportive relationships8. It is entirely possible, therefore, for individuals to feel profoundly lonely, even amidst a group8.
Although both loneliness and isolation have detrimental impacts on health9, social isolation – living alone or minimal interaction with family and friends – is more strongly associated with physical decline and premature mortality9. Conversely, loneliness predominantly predicts mental health challenges such as depression, loss of purpose, or existential despair9.
Interestingly, loneliness often permeates environments where one might least expect it, such as among busy professionals and affluent individuals, manifesting colloquially as ‘executive loneliness’; a unique form of emotional disconnection despite apparent external abundance.
Loneliness and mental health
Loneliness extends beyond emotional discomfort – it can profoundly impact both biological and psychological wellbeing. Strong associations exist between loneliness and physiological stress responses, significantly influencing overall physical and mental health outcomes10. Specifically, feelings of loneliness can disrupt the hypothalamic-pituitary-adrenal (HPA) axis – a vital pathway involved in stress regulation10.
From a biological standpoint, loneliness can trigger increased cortisol levels – something indicative of chronic stress responses10. Research demonstrates that feelings of loneliness experienced the previous day elevate cortisol awakening responses the following morning, while transient feelings of loneliness throughout the day cause immediate spikes in cortisol secretion10.
However, prolonged stress exposure also may predispose individuals to a heightened risk for loneliness and anxiety, alongside increased vulnerability to depression11. Indeed, loneliness correlates with an elevated likelihood of exhibiting symptoms consistent with major depressive disorder and possibly generalised anxiety disorder11. Yet, it’s important to recognise that loneliness alone does not invariably predict these mental health conditions, as some individuals who experience significant loneliness do not progress to these disorders11.
Psychologically, sustained loneliness can also significantly undermine mental resilience12, impairing emotional regulation and contributing to diminished perceptions of life’s meaningfulness12. Studies have clearly shown all dimensions of resilience negatively correlate with loneliness12, suggesting that isolated individuals often perceive their lives as lacking in purpose and direction12.
The connection between loneliness and addiction
Loneliness can significantly influence an individual’s psychological state, often prompting the adoption of maladaptive coping mechanisms, including substance use and other addictive behaviours. While loneliness itself may not directly cause addiction, evidence strongly indicates it serves as a substantial underlying risk factor for substance dependency. Crucially, loneliness and substance misuse can mutually reinforce one another14. For example, feelings of isolation lead to increased risk of substance abuse, as individuals may seek temporary relief from emotional distress14. Conversely, substance misuse can exacerbate feelings of isolation, creating a cyclical pattern that deepens both conditions14.
Exploring addiction’s roots in social isolation, the influential theories proposed by Johann Hari draw compelling insights from scientific research, particularly the renowned “Rat Park” studies. Conducted by scientist Bruce Alexander et al., these studies revealed striking behavioural differences between isolated rats and those within socially enriched environments. Rats confined alone consistently chose drug-laced water over plain water, often to the point of overdose15. Conversely, rats placed within an engaging social setting – complete with ample space, stimulating activities, and companionship – predominantly opted for drug-free water, even those previously habituated to addictive substances15.
This concept is particularly pertinent for successful individuals or those within affluent socioeconomic circles, where social isolation or emotional loneliness may not be overtly visible, yet profoundly affects wellbeing. Faced with significant pressures, these individuals might disguise emotional vulnerabilities behind alcohol or substance misuse, exacerbating underlying loneliness and fostering potential addiction risks.
Executive loneliness … ‘It’s isolating, at the top’
Executive loneliness is a uniquely challenging form of emotional isolation affecting senior leaders, including C-suite professionals. Despite appearances of strength and success, recent research reveals that 49% of CEOs report experiencing mental health difficulties, with the majority feeling overworked, fatigued, and under constant stress16. Notably, mental health conditions may be more prevalent among CEOs due to traits intrinsic to effective leadership, such as vigilant multitasking, forward-thinking strategies, and a perpetual focus on high quality16.
For executives, isolation often arises from specific workplace dynamics. Social norms can become increasingly ambiguous following promotions, complicating previously straightforward interactions17. Casual invitations, once easily accepted, now carry implicit professional considerations17. Moreover, the shift from a wide peer group to a smaller circle can leave senior leaders feeling unexpectedly adrift17. This diminished peer network reduces accessible emotional and professional support, exacerbating feelings of isolation17.
Further compounding such isolation is the distancing effect that executives experience with former colleagues upon transitioning into management roles17. Friendships that once provided emotional support become constrained by new power dynamics, amplifying a sense of emotional detachment17.
The consequences of prolonged executive loneliness are significant: over 70% of newly appointed CEOs report feelings of loneliness18, substantially increasing their vulnerability to burnout, depression, and substance dependency17. Unaddressed, these issues frequently precipitate rapid turnover and reduced productivity, highlighting the critical need to prioritise mental health in C-suite professionals and proactively address burnout in executives.
Recognising and addressing loneliness
Early identification and proactive mental health care by healthcare professionals are vital in helping to overcome the impacts of loneliness effectively. Recognising loneliness as a key underlying factor in broader mental health challenges can help break persistent cycles of isolation and addiction, underscoring the importance of integrating social connection into treatment frameworks.
For GPs, psychiatrists, and healthcare providers – considering social wellbeing, not merely as supplementary, but as fundamental for patient care plans significantly strengthens outcomes, bolstering overall emotional resilience and enhancing long-term addiction prevention.
If you, or someone you know is affected by any of these issues – get in touch with our team today.
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3890922/
- https://www.ons.gov.uk/peoplepopulationandcommunity/wellbeing/bulletins/publicopinionsandsocialtrendsgreatbritain/13december2023to1january2024
- https://www.who.int/teams/social-determinants-of-health/demographic-change-and-healthy-ageing/social-isolation-and-loneliness
- https://www.dailymail.co.uk/health/article-1298225/Loneliness-killer-Its-bad-health-alcoholism-smoking-eating-say-scientists.html
- https://guilfordjournals.com/doi/abs/10.1521/suli.31.1.32.21312
- https://jamanetwork.com/journals/jamapsychiatry/fullarticle/482179
- https://www.independent.co.uk/life-style/health-and-families/health-news/loneliness-can-increase-alzheimer-s-risk-8405166.html
- https://www.york.ac.uk/media/crd/Loneliness%20and%20social%20isolation.pdf
- https://www.health.harvard.edu/mind-and-mood/loneliness-vs-isolation-which-one-is-worse
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2841363/
- https://www.nature.com/articles/s41598-022-13049-9
- https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-020-00493-3
- https://bpspsychub.onlinelibrary.wiley.com/doi/full/10.1111/bjc.12358
- https://americanaddictioncenters.org/blog/loneliness-and-addiction
- https://www.deconstructingaddiction.com/johann-hari-interview
- https://hortoninternational.com/is-there-mental-health-support-for-your-ceos
- https://www.harvardbusiness.org/new-to-leadership-heres-how-to-address-loneliness/
- https://hbr.org/2012/02/its-time-to-acknowledge-ceo-lo